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Michael S. Watson, executive director of the American College of Medical Genetics, said that many mutations even in disease-causing genes do not produce serious or even detectable illness.

From this experiment, it appears that speed-independence is a fragile property that is easily destroyed by random mutations even in cells that are otherwise viable.

Exceptionally high level of germ line SNP mutations in RASSF1A found in several studies [8] support our data that the two genes we studied have rather frequent mutations even in normal cells.

Both assays have a sufficient analytical sensitivity to efficiently detect KRAS mutations even in samples with < 10% tumor cells.

Of great interest is that all SCA2 parkinsonian patients were sporadic cases, emphasizing the need to screen for SCA2 mutations even in patients with nonfamilial parkinsonism [ 28].

Baker et al. show that mutations in these genes confer a measurable fitness advantage over strains without these mutations, even in the absence of exposure to fluoroquinolones.

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This advantage was present in patients, having either BRCA 1 (HR 0.20; 95% CI, 0.12 – 0.32), or BRCA 2 (HR 0.21; 95% CI, 0.02 – 1.91) mutations even if in the latter group a small number of patients may affect the strength of evidences.

There was no distribution difference in ER β cytosolic expression and positive EGFR mutation, even in weak expression group.

This finding was not surprising, given the worldwide low frequency of this mutation, even in severe infections.

In the patients studied, a disruptive mutation even in only one allele of the STXBP2 gene resulted in a significant defect in platelet secretion (Al Hawas et al, 2012).

We showed that clonal interference impeded the rate of spread of the BoxG18A mutation even in the population in which it was substituted.

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