Sentence examples for mutations however in from inspiring English sources

Converse to this harmless effect of simple mutations, however, in silico modeling suggests that simultaneous mutation is lethal for phenotype in cancer cell growth, a finding that agrees with already published reports.

It is estimated that, in common adult epithelial tumours, there are on average 5 7 driver mutations; however, in haematopoietic malignancies this number might be lower (Stratton et al., 2009).

The detection of recurrent mutations in genes and pathways in cancers (Tamborero et al., 2013) has resulted in a growing catalogue of known cancer mutations, however, in any individual tumour, only a subset of these mutations is present, and how they cooperatively produce the cancer phenotype is often not well understood.

Even with a 10-fold input advantage, the 3D-G64S virus was unable to compete with 3D wild-type virus in the context of the revertible attenuating mutation; however, in the context of a non-revertible version of the 2C-F28S attenuating mutation, 3D-G64S virus matched the replication of 3D wild-type virus.

Inactivation may be due to a specific reason such as a mutation, however in the case of myosin motility we observe it in all samples, so the inactivation is probably a result of protein damage.

Other mutations, however, result in a loss of function in the gene they affect.

Unlike SOS1 mutations, however, those in SOS2 are restricted to the DH domain.

Many such mutations, however, occur in genes that encode for proteins of unknown function, which limits our molecular understanding of, and ability to devise treatments for, human disease.

Single mutations, however, result in either the malfunctioning of MMP-20 or KLK4, causing the hereditary disease amelogenesis imperfecta, which is characterized by very fragile teeth [58,59].

We found that 1% of GBMs have DAXX alterations (missense mutations); however, a difference in overall survival rate compared with non-altered cases was not apparent (Supplementary Fig. 19a, P value 0.544).

These mutations, however, were observed in only 3 out of 53 patients.