Sentence examples for mutations designed to from inspiring English sources

We now report the consequences of mutations designed to constitutively activate (Q204-L and R178-C) CPG-1-mediated signaling.

Here we test this hypothesis directly by introducing mutations designed to prevent formation of these nonnative interactions.

As a second alternative, the stability of a suboptimal framework can be improved by the introduction of point mutations designed to optimize key residue interactions.

However, structure-based mutations designed to disrupt potential B7-H6 dimerizathroughrough this site did not diminish NKp30-mediated cell activation.

Using an in vivo minigenome replication system, we engineered mutations designed to disrupt potential base pairing in the viral RNA termini.

Taking advantage of our high resolution structure, the reciprocal impact of rational mutations designed to disrupt aminoacylation or cytokine signaling was investigated with multiple assays.

The patented bird carries a genetic mutation designed to suppress the "white gene" in baby turkeys and then allow it to emerge in adult birds.

A mutation designed to negate the GTPase activity of the protein produced similar phenotypes, but was genetically dominant.

VP35 mutants lacking the coiled-coil motif or possessing a mutation designed to disrupt coiled-coil function were defective in oligomerization, as deduced by co-immunoprecipitation studies.

The genetic algorithm consists of a modifying version of the classical genetic operations of initialisation, selection, crossover and mutation designed to incorporate practical but general principles of model calibration without reference to any specific problems.

RluF does not modify U2604 in mutant stem loops that lack the A2602 bulge and shows dramatically higher activity for a stem loop with a mutation designed to facilitate A2602 refolding into the stem with concomitant RNA strand translation.