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Exact(6)
Assuming that mutations conferring the ability to fix N have appeared without bias across the potentially N-fixing clade, N fixation has likely appeared in late-successional taxa, but the combination of N fixation and a late-successional strategy has been selected against.
Various mutations conferring the increased thermal tolerance to the strains are identified and their possible effects discussed.
As a well-known example, mutations conferring the bacterial TEM-1 lactamase with resistance against third-generation antibiotics were found to be destabilizing [ 7].
Although most of the new inhibitors were not originally designed to target the secondary mutations conferring the resistance to crizotinib treatment, they were highly potent against both wild and mutant ALK kinases.
As Table 3 shows, several of the different lines independently converged upon the same mutations suggesting that these mutations, conferring the ability to withstand extreme temperatures, may: (1) be preferred sites of heat mutagenesis [ 15] while (2) maintain the phage's ability to infect and replicate successfully within its host.
Factors presumed to prevent or slow the evolution of antibiotic resistance include the limitation of mutations conferring the resistance and the fitness costs associated with the resistance (Andersson 2006; Read and Huijben 2009; MacLean et al. 2010; Andersson and Hughes 2011; Cantón and Morosini 2011; Hermsen et al. 2012).
Similar(54)
These mutations confer the essential features of ion conduction in the cyclic nucleotide-gated ion channels; the mutant K+ channels display little selectivity among monovalent cations and are blocked by divalent cations.
Rather, we proposed that the location of mutations confers the proteins with their amyloidogenic potential.
These results indicate that egl-8 mutations confer the strong suppression for the synaptic defects in ttx-7 mutants.
Critically, transfer of the mutant alleles into a wild-type E. coli background confirmed that the rpoB and rpoC mutations conferred the greatest increase in growth rate in the same medium.
The parental cells were transfected with a native BCR-ABL1 or its mutated variant, carrying the Y253H mutation, conferring the resistance to imatinib in these cells.
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