Sentence examples for mutations along a from inspiring English sources

Leskovec says that much of the software he used to track slight variations on a phrase were borrowed from the world of genetics, where software helps track mutations along a DNA strand.

The fitness interactions between the mutations along a drug-resistance pathway are expected to have an impact on the relative mutant frequencies in a viral population.

Also, we use the result that the number of mutations along a genealogical branch is Poisson distributed, and because we restrict our attention to neutral loci, we separate the mutation process from the genealogical process (Tavaré 1984; Hudson 1990).

To deal with this absence, we assume that the reads arise from unobserved haplotypes the lineages with variation appearing either from mutations along a phylogenetic tree or from errors in sequencing, informatics, or SNP calling.

Detection of compensatory or semi-compensatory mutations along a multiple alignment is the main tool employed for inferring ribosomal RNA secondary and tertiary structures [ 38, 40], and has been largely confirmed by crystallographic results [ 41].

However, Gong et al. go further by investigating nearly all naturally occurring mutations along a relatively long evolutionary path (consisting of 39 steps), and by examining the causes of these epistatic interactions.

A straightforward and complementary approach to measure fitness interactions relies on the construction of HIV variants with all mutations along an evolutionary pathway, then measuring their individual and combined fitness effects, and comparing the results with predictions generated under the null hypothesis of non-epistatic interactions [18].

First, it can be used as an alternate approach to model-free filtering of instrumental noise by taking advantage of the correlation of true mutations along an allele while eliminating the high level of uncorrelated noise typical of massively parallel sequence data.

Laminopathies encompass a wide array of human diseases associated to scattered mutations along LMNA, a single gene encoding A-type lamins.

After transfection of these cells with a plasmid expressing Cas9 and a guide RNA (gRNA-27) targeting a site nearby the BFP/eGFP mutations, along with a repair template containing a partial WT eGFP sequence, the fluorescent marker switch from BFP to eGFP can be easily detected and the gene editing frequency quantified by flow cytometry (Fig. 1B).

This contrasts with the Prp8p gene, which shows a much lower rate of missense to silent mutations along with a five-fold higher rate of silent substitution with selection.