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The exclusion of two interior water molecules by the Thr88Ile mutation, and the relief of adjacent conformational stress by the Tyr16Ser mutation were the major contributions to the thermostability.

The patient and her sister carrying the same mutation were the daughters of a breast cancer patient diagnosed with the disease at 38 years of age.

Cases with a single mutation, in which cells with no mutation were the only heterogeneous subpopulation, were excluded because such a subpopulation was difficult to distinguish from normal epithelial cells.

The E746_A750 deletion and L858R substitution mutation were the most common (8 out of 9, 88.9%), and both are well-known hot spot mutations described previously (Kosaka et al, 2004; Han et al, 2005).

Our results revealed that the deletion in exon 19 and the L858R point mutation were the major EGFR mutations in lung adenocarcinomas, and EGFR mutations were significantly associated with smoking status.

Nilotinib was rationally designed after the discovery of resistance to imatinib in early clinical trials [ 6- 8] and laboratory evidence showing that point mutations in the BCR-ABL1 kinase domain mutation were the most common cause of such resistance [ 9].

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Similar(49)

To me, mutation is the answer to everything.

In Bioshock, human mutation is the extreme consequence of unbridled capitalism and scientific experimentation.

The most damaging consequence of cell mutation is the development of cancer.

Perhaps the most radical mutation is the duplication of an entire set of chromosomes.

The signature mutation is the K65R mutation, which causes variable loss in susceptibility to tenofovir DF, didanosine, and abacavir.

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