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All Hm-WT and heterozygous plants were susceptible to PVY-LYE90 and PepMoV whereas all plants homozygous for the mutation were resistant to both viruses, confirming that resistance indeed results from mutation in Sl-eIF4E1.
Most recently, a number of reports indicated that several clinically isolated 2009 H1N1pdm strains with NA H260Y mutation were resistant to the NA inhibitor oseltamivir [20], [21].
Similar to vps53Δ cells, cells harboring the Q624R mutation were resistant to myriocin treatment.
As expected, LAT-1 proteins containing either mutation were resistant to autocatalytic cleavage but were expressed normally.
In previous studies, all the strains [ 10, 29] or most of the strains [ 1] with this mutation were resistant to KAN, whereas Engstrom [ 15, 28] reported that 85% of the strains were sensitive.
From the published data, eis c-12t) is moreis c-12tound is sensitive strains than in resistant strains [ 1, 10, 15, 28], with only one report indicating that all 4 strains with this moretioftenre resistant to KAN [ 29].
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For example, people with the CCR5-Δ32 mutareon aresistantantoto infection with R5 virus, as the mutation stops HIV from binding to this coreceptor, reducing its ability to infect target cells.
The T315I gatekeeper mutation is resistant to the three Bcr-Abl inhibitors that are currently approved for the treatment of Chronic Myelogenous Leukemia: imatinib, nilotinib and dasatinib.
On the other hand, NSCLC with exon 20 mutation is resistant for EGFR-TKI.
In addition, K437R-BECN1 mutation was resistant to RNF2 deletion-induced enhancement of autophagy (Supplementary information, Figure S3C).
Patients with a tumour harbouring a KRAS codon 12 or 13 mutation are resistant to anti-EGFR therapy[ 1, 5].
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