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Noteworthy, 4 KIT negative GIST with PDGFRA mutation were positive for NTSR1 staining (Fig. 3B).
Remarkably, six cases of lobular breast cancer without a detectable E-cadherin mutation were positive for E-cadherin immunostaining.
Four of the five occult tumours and two papillary serous peritoneal carcinomas of women with a BRCA1 germline mutation were positive of P53 protein.
For the double and triple mutants, only combinations of the individual mutations with a PFLU4744 mutation were positive for calcofluor and Congo red binding.
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The KCNJ11 gene mutation was positive for the baby.
This also allows us to determine whether the effect of the QTL mutation is positive or negative for each trait.
In our case, since the BRAF mutation was positive, we used vemurafenib for treatment, and the patient was responsive to it.
In our study, genetic testing was not consistently performed in all young patients and BRCA mutation was positive in 10 out of the 19 young women that were tested (data not shown).
The breast tumor of the patient harboring the p.P92R missense mutation was positive for ER, which is consistent with previous findings that breast tumors linked with CHEK2 frame shift and missense mutations (c.1100delC, c.IVS2 +1G>A, del5395, p.I157T) are predominantly ER-positive [ 48- 50].
PIK3CA mutations are positive prognostic factors in breast cancer [ 21, 22], supporting the clinical utility of MPS for the detection of clinically actionable mutations.
In fact, the relationship between original deletion effect and average effect of secondary mutations was positive and non-significant (r = 0.486, P = 0.407).
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