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In terms of leaf length, the effect of the slr1 mutation was much more obvious in the wild-type background than in the pla1 mutant background.
Podlutsky's dissertation showed that the rate of mutation was much higher in cells from old mice than in young ones and that a diet of antioxidants reduced the mutation frequency in the elderly rodents to the same level as that seen in the juveniles.
Similar results were observed in T-47D cells, although the effect of the GA mutation was much less.
Therefore, it can be concluded that at the protein accumulation level, the impact of the gln1.3 mutation was much stronger than that of gln1.4.
From the metabolite profile at the V stage, it would appear that the impact of the gln1.3 mutation was much greater than that of the gln1.4 mutation.
The loss on mutation was much more dramatic for mutations according to PAM120 (yellow in Fig. 3C) than for those according to the background distribution (green in Fig. 3C).
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The probability of pathogen to overcome two or more effective genes by mutation is much lower compared to the 'attacking' of resistance controlled by a single gene.
Immune escape is generally attributed to reduced antibody recognition of the viral hemagglutinin and neuraminidase proteins whose rate of mutation is much greater than that of the internal non-structural proteins.
The FSIQ correlation of 0.98 for DMD siblings and 0.83 for unrelated DMD-affected individuals with the same mutation is much higher than that previously reported for unaffected male siblings reared together (median correlation of 12 studies 0.38).
It should be noted that in some cases observation of the same mutation in two different strains might be due to selection (e.g. if a specific mutation is much more likely to cause the phenotype than other mutations are, or if only a small number of different mutations in the genome are capable of causing the phenotype), rather than due to common inheritance.
The HOXB13 G48E mutation is much more common in Sweden than in Poland (Karlsson et al, 2012).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com