Consistent with our previous observation, the binding of calnexin C-tail to the rIII-IV linker (+25) containing the GAERS mutation was significantly decreased by 82% (p < 0.001) compared to the wild-type rIII-IV (+25) (Fig. 6B and C).
"We found that the mutation was significantly more common in men with a family history and early diagnosis compared with men diagnosed later, after age 55, without a family history.
In these core isolates the Y976F mutation was significantly more prevalent in Indonesian isolates (96%, 24/25) compared to Thai isolates (43%, 3/7); p = 0.004.
Notably, RB1CC1 biallelic mutation was significantly infrequent (two of 38 cases, 5.3%) relative to the expected frequency based upon mutant allele incidence (13.6%, five of 38 cases; Fisher's exact test p value, 0.01).
There was no difference between telomere lengths of the reference population and the unrelated spouses, but we find that the mean telomere length of related family members without a TERT mutation was significantly shorter than the reference population (P-value = 1.01×10−5).
In a study from Kazakhstan [43] all MDR strains, irrespective of genotype, carried the mutation at codon 315 of the katG gene, and in a group of INH resistant but RIF sensitive strains, this mutation was significantly more prevalent in the Beijing than in the non-Beijing group of strains [43].
The frequency of kl-vs mutation was significantly different from previous studies in different populations.
The presence of the G1613A mutation was significantly higher in the group that later developed HCC.
The FVL mutation was significantly associated with an increased risk of admission to intensive care.
The incidence of KRAS mutation was significantly higher in female and younger patients (P < 0.05).
Additionally, p53 mutation was significantly less frequent in the luminal A subgroup (P < 0.05).
