Sentence examples for mutation shifts the from inspiring English sources

This explains why ADP binds Kir6.2 with a lower affinity and the R50 mutation shifts the IC50 curve to a similar range of ADPβS on wild-type channels (Schwanstecher et al., 1994a; Shimomura et al., 2006).

It has been reported that the M153A mutation shifts the excitation wavelength of GFP S65T) to a longer wavelength [12].

The shift in the pH-dependent equilibrium upon replacing Ala2 with Val, without a change in SH parameters, suggests the side chain of the second residue plays a similar indirect role, however the A2V mutation shifts the equilibrium in the opposite direction (subtle decrease in high pH mode) compared with the D1N mutation (significant increase in high pH mode).

Our interpretation is that the inverting mutation shifts the population of SRI−HtrI complex molecules from the high-p Ka conformer to the low-p Ka conformer.

Sequencing the RT-PCR product with oligonucleotides used for amplification showed that the mtp5-1 mutation shifts the splice site 1 bp 3′ of the original site.

Destabilization by pH or His-104 mutation shifts the ACD from dimer to monomer but also results in a large expansion of HSPB5 oligomer states.

According to this model, familial Alzheimer's disease (FAD) PS1 mutations shift the equilibrium to favor a "close" NT-CT conformation (with NT-CT closer together) and stabilize an alignment of the PS1/γ-secretase active site with the APP substrate to favor predominant cleavage of APP at the Aβ42 position.

Signal-inverting mutations shift the equilibrium in favor of the outwardly accessible Schiff base form.

Thus, we assumed that additional single site mutations shift the λmax by ± 1 nm.

In addition, it is reasonable to assume that unknown single site mutations shift the λmax of the pigments slightly.

In addition to increasing the quantum yield and solubility of the proteins these mutations shift the spectral profiles of the translation products [ 4, 11].