Sentence examples for mutation rendering the from inspiring English sources

Here, I show that mice engineered to carry a germline point mutation rendering the propeptide protease-resistant exhibit increases in muscle mass approaching those seen in mice completely lacking myostatin.

Although these findings were consistent with the point mutation rendering the latent myostatin complex resistant to activation by BMP-1/TLD proteases, it was important to rule out the possibility that the point mutation caused increased muscling by decreasing myostatin expression levels.

SKMEL13 melanoma cells carry the BRAF V600E) mutation rendering the ERK signalling pathway constitutively active.

When a lentiviral genome was included for example as a carrier of a HR donor sequence, we referred to this vector as an IDLV (due to presence of the IN D64V mutation, rendering the vector integrase-defective).

We began by incorporating ZFNs targeting the egfp reporter gene (Urnov et al., 2005) into the gag gene of a packaging construct harboring the IN D64V mutation, rendering the viral integrase (IN) incapable of catalyzing vector insertion.

The work presented here is suggestive of this second set of possibilities, because many of the effects we observe are indicative of a general lack of robustness of the adaxial patterning system, with the rps10b-1 mutation rendering the system sensitive to the dosage of other important regulatory components.

The M766D mutation renders the enzyme incapable of supporting the temperature-sensitive strain at a non-permissive temperature.

The Bsdr1 mutation renders the plant shorter with fewer tillers, but not severely abnormal as is common with many gain-of-resistance mutants in Arabidopsis (Shirano et al. 2002; Vogel and Somerville 2000).

This mutation renders the enzyme inactive, since Asp102 is a catalytic residue.

This mutation renders the clock arrhythmic and the SDS-PAGE analysis indicates that KaiCI430A is hyper-phosphorylated (Fig. 3).

This insertion mutation renders the GH receptor nonfunctional and causes severe GH resistance, leading to suppression of peripheral IGF-1 and insulin levels.