Sentence examples for mutation conferring the from inspiring English sources

The parental cells were transfected with a native BCR-ABL1 or its mutated variant, carrying the Y253H mutation, conferring the resistance to imatinib in these cells.

The critical mutation conferring the first level of chloroquine resistance is found in aat1, a putative aminoacid transporter.

If the V2728F ubp1 point mutation is the sole mutation identified on chr02 and if that mutation arose between the isogenic sensitive and resistant parasite, it must be considered the critical mutation conferring the resistance phenotype.

Thus, with a total of four hybridization experiments (one per mutant line), the location of the mutation conferring the phenotype was narrowed to a 70 kb region (21 gene models) on chromosome 12.

Previous classical linkage analysis of a genetic cross between the CQ-R mutant AS-3CQ and a genetically distinct sensitive strain, AJ, defined a region of 250 kb on chromosome 11 (chr11) as that containing the mutation conferring the first level of CQ-R [ 19, 20] but the critical gene or mutation was not identified.

When it was mutated to alanine, about 30% of the activity was observed, and the mutation conferred the resistance to Cap-40 and AzQ.

In order to identify which reverse mutation confers the fluorescent phenotype, we constructed a second series of vectors, pEM7 SHM vectors, with the EGFP gene under the control of both a prokaryotic (EM7) and a eukaryotic (CMV) promoter.

The current mutator hypothesis speculates that a small number of 'driver' alterations exist and, once acquired by somatic mutation, confer the cancer phenotype; however, seemingly insignificant 'passenger' mutations result via mechanisms yet to be elucidated [ 26].

Various mutations conferring the increased thermal tolerance to the strains are identified and their possible effects discussed.

As a well-known example, mutations conferring the bacterial TEM-1 lactamase with resistance against third-generation antibiotics were found to be destabilizing [ 7].

Although most of the new inhibitors were not originally designed to target the secondary mutations conferring the resistance to crizotinib treatment, they were highly potent against both wild and mutant ALK kinases.