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RNA viruses have high mutation rates owing to lack of proofreading of the RNA polymerase.
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However, an enhanced mutation rate owing to the hatchery environment is one possibility.
DNA divergence observed in existing landraces, cultivars, and wild relatives can now be determined accurately, so the order of major DNA changes such as single nucleotide polymorphisms during the domestication process can be abducted owing to relatively low mutation rates.
However, mutation rates could be slower in subterranean organisms owing to longer generation times [ 31].
Indeed, the signature of bottlenecks might have been underestimated by our SSR markers, owing to their high mutation rates that are able to quickly replenish diversity losses typical of domestication processes (Glemin and Bataillon 2009).
It should be noted that highly expressed genes actually experience greater mutation rates than the remainder of the genome owing to their extended exposure as single strands (Ochman 2003; Lind and Andersson 2008), so it is enhanced purifying selection and not reduced mutation that explains their slow evolution.
For deleterious mutation rates and the evolution of sex see, for example, Kondrashov, A. S. 1988.
The commission wanted thousands of Yanomami blood samples to determine genetic mutation rates in a population completely uncontaminated by radiation.
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