Sentence examples for mutation in terms from inspiring English sources

Thus, the significance of this mutation in terms of pathogenicity needs to be verified.

Since 2004, the predictive value of somatic KRAS mutation, in terms of resistance to anti-EGFR mAbs, has been established by numerous studies.

Further, it will better define the mutation in terms of its effects on primary cell wall elongation and early secondary cell wall synthesis.

The kinetic advantage afforded by the Q115E mutation in terms of TCR/pMHCI binding is likely to enhance antigenicity per se.

Interestingly, only the snc1 allele behaves like a conventional mutation in terms of its phenotypic stability, as expected from this allele's known molecular nature.

These data indicate that the PNPLA3 148M is a loss-of-function mutation in terms of regulation of lipid droplet metabolism in human HSCs.

In the subgroup of 24 patients without detectable mutation within KRAS, BRAF and PIK3CA, we observed, in this small sample, a trend but not significant difference between the group of patients with (18) and without (6) TP53 mutation, in term of CD (a TP53 mutation was found in 15 out of 19 (79%) patients with CD as compared to 3 out of 5 (60%) with PD, P=0.568) and TTP (20 vs 12 weeks, P=0.0931).

(B ) Identity and fate of the mutated bases (as percentages of the total mutations) in terms of top strand sequence induced by repair that either restored lesions to C/G (left quadrants) or converted T/G to T/A (right quadrants, gray box) for top strand (upper two quadrants) and bottom strand (lower two quadrants) lesions on FM1.

In this case, the top strand serves as the repair template, but because we show all the mutations in terms of the top strand sequence the final mutational outcome is basically the complement of the results generated from the repair of top strand lesions.

Here, we evaluate the most widely-used methods for the detection of on-target and off-target mutations in terms of workflow, sensitivity, strengths and weaknesses.

The effects of both Q212P and R220K mutations in terms of unstructured C-terminal parts of proteins are comparable (Figures 7A and B).