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But how did mutation hotspots come to be concentrated where they are needed?
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New Haven's restaurant hotspots come alive at night.
Mutation hotspots and showers occur across phylogeny and profoundly influence genome evolution, yet the mechanisms that produce hotspots remain obscure.
A total of 39 point mutation hotspots were discovered (Supplementary Table S2).
The accumulated mutations differ across mutator strains, displaying base-substitution biases, allele-specific mutation hotspots, and break-associated mutation clustering.
Additionally, microsats are distributed throughout the genome of animals and are mutation hotspots.
These mutations are not distributed at random, and bladder-specific mutation hotspots have been reported at codons 280 and 285.
p53 mutations do not occur in a random fashion along the coding sequence but are typically clustered at so-called mutation hotspots.
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