Sentence examples for mutation has led from inspiring English sources

Characterization of this mutation has led to the development of a transgenic approach that was used to increase methionine concentration [ 12].

The presence of SNPs in the adjacent region of the non-sense mutation has led the authors to propose a convergent evolution.

Hence, we have here an example where a recessive mutation has led to what I consider a clear case of parapatric speciation by provoking a switch to a different pollinator, which presumably allowed M. cardinalis to colonise the lower ranges and valleys where hummingbirds are found.

Targeting a subset of a particular cancer type with an identifiable driver mutation has led to remarkable successes in the past few years, exemplified by vemurafenib treatment of BRAF-mutated melanoma (Chapman et al, 2011) and crizotinib treatment of ALK-rearranged NSCLC (Kwak et al, 2010).

For instance, in lung cancer the identification of echinoderm microtubule associated protein like 4 - anaplastic lymphoma kinase (EML4-ALK) mutation has led to a targeted approach with crizotinib and tumors with epidermal growth factor receptor (EGFR) mutations to the development of erlotinib or gefitinib.

This mutation had led to a change in the predicted amino acid sequence; the lysine at codon 24 in the wild-type MAX protein was changed to a glycine in the mutant MAX protein, and a stop codon was located 40 codons downstream from codon 24.

Furthermore, studies that evaluated disease outcome according to the type of PIK3CA mutation have led to different conclusions.

The results in Figure 2c indicated that the p.Trp43Arg mutation had led to a red shift of the Emax to ∼ 329 nm, implying that the mutation might result in an alternation in the microenvironments of the other three Trp residues.

Although several antibiotics have been developed to manage these diseases with optimum efficacy, their mismanagement and maladministration, as well as microbial mutation have led to the emergence of drug-resistant strains.

This biased distribution of FGFR3 and TP53 mutations has led to the hypothesis that UC develops along two different pathways, a FGFR3 and a TP53 pathway, respectively [1], [2].

20 The identification of NLRP3 gene mutations has led to the recognition of FCAS, MWS, and CINCA as a continuum of pathologically related conditions called cryopyrin.