Sentence examples for mutation explains the from inspiring English sources

We conclude that this mutation explains the kidney disease in these 11 family members.

The activation of KRAS signalling through the LCS6 mutation explains the inability to find activating mutations in the coding regions of KRAS in humans with endometriosis.

We believe that in our patient the IVS14+1G>A mutation explains the dramatic reduction in 5-FU clearance compared to controls.

Furthermore, we showed that the co-occurrence of Y791F with the strong RET C634Y mutation explains the aggressive MTC phenotypes observed in a large affected family that was initially reported as Y791F-only.

We confirmed that the nudE nonsense mutation explains the 11R2 phenotype by showing that germline clones of nudE 39A, a previously described null allele (Wainman et al. 2009), also fail to specify an oocyte.

Assuming that a single causative mutation explains the phenotypic effects observed in each mutant (Table 1), a mapping power >97% is expected for bulks consisting of 2 × 10 cells sorted from the 2% tails of the fluorescence distribution, with 20 generations of growth and an average sequencing coverage of at least 75× (see Figure S4).

Thus, the H allele may be an M allele having lost the dominant female sterility mutation, explaining the dominance of the M allele over the H allele.

The presence of the BRCA2 mutation explained the occurrence of breast and ovarian cancer in the kindred, and presence of the MSH2 mutation accounted for CRC, endometrial and brain cancer (astrocytoma).

We hypothesize that the mutant alleles of Celsr1 Crsh and Vangl2 Lp lead to greater disruption of the pathway than the Scrib Crc mutation, explaining the greater severity of phenotypes in crosses involving the Celsr1 Crsh and Vangl2 Lp alleles.

Actin three-dimensional molecular modeling revealed critical positioning of R179 at the interface between the two strands of filamentous actin and destabilization of inter-strand bundling by the R179H mutation, explaining the severe associated phenotype.

Once the candidate region spans only a few megabases, re-sequencing will be performed in HH and hh animals with the purpose of identifying the mutation explaining the phenotype in question.