Sentence examples for mutation both in from inspiring English sources

Supporting the concept that relatively high level mosaicism is required to develop the full CFNS phenotype, the one previously described male mosaic for EFNB1 mutation, who had low levels of mutation both in blood (3%) and hair roots (2%), only manifested the mild features associated with the male carrier state (14).

Hematopoietic stem cell transplantation (HSCT) is one of the first choices for the treatment of ARO and lessens the severity of V-ATPase a3 mutation both in humans and mice [15], [33].

RG7204 (PLX4032), a selective BRAF V600E inhibitor, has potent inhibitory effects on the growth of melanoma harboring this mutation both in vitro and in vivo [ 51].

The genes MEIS1, ZEB2, SRGAP2P1, TMEM30A, AK2, TMED2, HIPK3 and FAM62B showed marked up-regulation in patients with MLL mutation, both in ALL and AML.

Fifty-eight out of 100 specimens had the same silent mutation, both in heterozygotic and in homozygotic status, on the codon 787 in exon 20.

Dasatinib has since been shown to have a selective inhibitory effect in this KIT mutation both in vitro and in the clinic in the setting of previous imatinib therapy (Woodman et al, 2009).

Direct sequencing analysis was negative for small mutations both in CACNA1A and in ATP1A2 exons.

Mitochondrial damage can be inherited via mutations both in maternal DNA (mtDNA) and nuclear DNA, and present at birth or remain latent until triggered later in life.

Thus, the double hit theory, mutations both in mitochondrial DNA and modifying genes aggravating the symptom, throws new light on mitochondrial dysfunction processes.

It proves that JE virus is making possible modifications in antigenic structure through mutations both in nucleotide and protein sequences.

HIV drug resistance mutations both in peripheral blood mononuclear cells (PBMCs) and plasma have the ability to influence the outcome of highly active antiretroviral therapy for HIV patients.