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A first mutation may have occurred in mutT4 and thereafter a second mutation either in mutT2 or ogt was acquired.
A gene could be inactivated by a mutation either in a control site or in a coding region [ 47].
Alternatively, the toxin gene may not be expressed due to mutation either in the coding region or in a regulatory region, for example, agr [ 42, 43].
Mutation either in the PKD1 (approximately 85% of patients) or PKD2 gene (approximately 15%) cause ADPKD, with an average age of 54.3 and 74 years, respectively, at the onset of ESRD (end stage renal disease) [ 1].
However, although our study confirms that basal CKs can help to identify BRCA1 mutation carriers, this effect was weaker than previously suggested and CKs did not independently predict BRCA1 mutation either in sporadic or familial breast cancer cases.
Two lig4 stocks carried the lig4 mutation, either in a wild-type or w background (Bozas et al. 2009; McVey et al. 2004b), and some injections were performed in a stock carrying the lig4 EP385 mutation (Bloomington Stock Center).
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But, even some of those point mutations either in- or outside the polymerisation interface can affect MreB's function, as shown in Figure 5 figure supplement 1.
All mutations, either in a homozygous or compound-heterozygous state, disrupted the function of the gene.
There are already some smaller projects under way looking for mutations, either in a particular type of cancer or in particular types of genes.
By genetic analyses, this could be attributed to mutations either in the GLUT transporter sequence or in the genome of the yeast host.
Mutants resistant to trimethoprim contained mutations either in folA and/or its promoter or genetic amplification of a large region containing folA (Supplementary Data 4).
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