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In the genetic algorithm, tailor-made crossover, mutation and local search operators are designed.
In this process, a succession of steps with a mutation and local optimization (the method of Broyden-Fletcher-Goldfarb-Shanno [BFGS]) were conducted, and each step followed the Metropolis criterion [24].
An overall reduction in recombination intensifies background selection, but the degree to which its effects arise depends on the ratio of the deleterious mutation and local recombination rates [8].
No relationship was seen between PIK3CA, KRAS or BRAF mutation and local or distant recurrences.
No relationship was seen between PIK3CA, KRAS or BRAF mutation and local or distant recurrences and no longer with overall survival (all p< 0.01).
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Autodock Vina generates docking poses using an iterated local search global optimizer [23] which consists in a succession of steps of stochastic mutations and local optimizations [18].
ABSOLUTE [ 22] was used to estimate sample purity and ploidy and then calculate cancer cell fraction (inferred percentage of neoplastic nuclei that harbor a given mutation) and cell copy number of mutations and local DNA copy changes.
Then we evaluate several genetic operators, which include compounded partially mapped crossover (PMX), position-based crossover (PBC), swap mutation (SM), and local search-based mutation (LSM) in order to construct the flc-hGA which have the better optimal makespan and several alternative schedules with optimal makespan.
The limiting speed is proportional to μ1/2 and μ1/3 in linear and planar habitats, respectively, where the mutational supply μ is the product of mutation rate and local population density.
Moreover, a decision probability is used to control the utilization of genetic mutation operation and local search based on problem-specific information so as to prevent the premature convergence and concentrate computing effort on promising neighbor solutions.
In addition, features such as local mutation rate and local recombination rate, both of which are likely to influence patterns of polymorphism, have not been controlled for in previous studies.
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