hypothesis of mutation accumulation

USAGE SUMMARY

The phrase "hypothesis of mutation accumulation" is correct and usable in written English.
It can be used in scientific or academic contexts when discussing theories related to genetic mutations and their effects over time. Example: "The hypothesis of mutation accumulation suggests that the gradual accumulation of mutations can lead to significant evolutionary changes in a population."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

1 human-written examples

Further tests of the hypothesis of mutation accumulation might more fruitfully focus on diseases 1) epidemiologically characterized by a very late and/or less variable age of onset and/or 2) with an abundance of common and ancient alleles.

Plosone

Human-verified similar examples from authoritative sources

Similar Expressions

59 human-written examples

Between-line variability in the rate of mutation accumulation.

Nature

For mutation accumulation, purging of the genetic burden may be more effective than hitherto suspected, suggesting a diminished role of mutation accumulation in determining mortality late in life.

Plosone

This is the method of "mutation accumulation" (MA).

Genome Biology and Evolution

Starting with mutation-free P. esculentus individuals, the diffusion of mutations passes through different stages of mutation accumulations.

BMC Evolutionary Biology

The fact that they are all mutators, however, is consistent with the hypothesis that mutation accumulation drove the observed phenotypic changes.

BMC Evolutionary Biology

One biological observation regarded as crucial support for the mutation accumulation hypothesis are the Virginia opossum.

Bioinformatics and Biology Insights

Thus simulations predicted some observations, and these observations do not contradict the mutation accumulation hypothesis in the Penna implementation.

Bioinformatics and Biology Insights

Two main classes of hypotheses have been proposed to explain its advantage: detrimental mutation clearance and beneficial mutation accumulation.

BMC Evolutionary Biology

Two hypotheses exist: either all the cell populations have the capacity to become tumourigenic through mutation accumulation, or this ability is confined to a select 'elite' group [ 1].

Breast Cancer Research

However, recent work in phage mutation-accumulation experiments suggests an increase in the relative incidence of beneficial mutations as fitness decreases in association with deleterious mutation accumulation [ 32].

BMC Evolutionary Biology

Expert writing Tips

Best practice

When discussing the "hypothesis of mutation accumulation", provide context about the specific disease or evolutionary process to which it applies to enhance clarity and relevance.

Common error

Avoid assuming the "hypothesis of mutation accumulation" always leads to negative outcomes; mutations can also drive adaptation and diversification.

Linguistic Context

The phrase "hypothesis of mutation accumulation" functions as a noun phrase that identifies a specific scientific hypothesis. It refers to a proposed explanation regarding how mutations accumulate over time and their effects on biological systems. Ludwig AI confirms its usability in scientific contexts.

Expression frequency: Rare

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

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Encyclopedias

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Ludwig's WRAP-UP

The phrase "hypothesis of mutation accumulation" is a noun phrase primarily used in scientific contexts to denote a specific theory concerning how mutations accumulate over time. Ludwig AI confirms its grammatical correctness and usability. While relatively rare in overall usage, the phrase is crucial in framing research and discussions related to the genetic basis of aging, disease, and evolution. It is important to avoid misinterpretations by acknowledging that not all mutation accumulations lead to negative outcomes, as mutations can also drive adaptation and diversification. Related terms include "mutation accumulation theory" and "mutational load hypothesis".

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

Mutation accumulation theory

Focuses specifically on the theoretical framework rather than the initial proposition.

Mutational load hypothesis

Emphasizes the burden of accumulated mutations on an organism or population.

Accumulation of genetic errors

Highlights the errors in the genetic material that arise over time.

Progressive mutation accumulation

Stresses the continuous and ongoing nature of the mutation process.

Hypothesis of increasing mutational burden

Explicitly points out that mutational burden increases over time.

Genetic mutation accumulation model

Refers to a model describing the process of genetic mutation accumulation.

Concept of accumulated mutations

Uses a broader term to refer to the general idea of mutations accumulating.

Drift-barrier hypothesis

Connects the accumulation of mutations to genetic drift and population size.

Hypothesis regarding mutation build-up

Uses an alternative term for accumulation and clarifies the focus on mutation.

Evolutionary accumulation of mutations

Specifies the evolutionary context in which mutations accumulate.

FAQs

What does the phrase "hypothesis of mutation accumulation" mean?

The "hypothesis of mutation accumulation" refers to the idea that genetic mutations build up over time, which can influence aging, disease, and evolutionary processes.

How is the "hypothesis of mutation accumulation" used in scientific research?

Scientists use the "hypothesis of mutation accumulation" to study the genetic basis of various phenomena, such as age-related diseases and adaptation to new environments. Further tests might focus on diseases epidemiologically characterized by a very late and/or less variable age of onset and/or with an abundance of common and ancient alleles.

What are some alternative ways to refer to the "hypothesis of mutation accumulation"?

You can use terms like "mutation accumulation theory" or "mutational load hypothesis" to convey a similar concept.

Is the "hypothesis of mutation accumulation" universally accepted in the scientific community?

While widely studied, the "hypothesis of mutation accumulation" is an area of ongoing research, and the extent of its role in various biological processes is still being investigated. Other factors, such as the epistasis between mutations increasing the adaptation to a new host, may be relevant.