Sentence examples for mutation abolishes the from inspiring English sources

(G) Statistical analyses of a luciferase reporter assay in 293T cells transfected with plasmids as indicated, which revealed that this rare mutation abolishes the suppression of RCAN1.4 on NFAT-mediated transcription.

This mutation abolishes the myristoylation activity of human Nkd2 [20].

The reduction of the enzymatic efficacy for cGMP might be interpreted by the fact that the Q453E mutation abolishes the hydrogen bond between NE2 of Gln453 and O6 of cGMP.

This mutation abolishes the binding and crosslinking of [H]azocholesterol to NPC1 (Ohgami et al., 2004).

The frameshift mutation abolishes the stop codon and extends the reading frame.

This mutation abolishes the canonical acceptor splice-site, but the expected skipping of exon 8 was not detected.

Interestingly we observed that the FYVE-CENT R1945Q mutation abolished the interaction between FYVE-CENT and Beclin 1 (Figure 2C).

Indeed, the Ser8 mutation abolished the binding of CGRRAGGSC to IL-11Rα; the Δδ observed in Ser8 induced by binding to IL-11Rα corroborated this result.

Such a mutation abolished the repressive effects that miR-20b had on luciferase activity (Fig. 3Ai), suggesting that miR-20b regulates PPARγ expression by directly binding to the 3'UTR site of PPARγ.

In this assay, the amount of purified recombinant RNPs is a measure of their replication in vivo, as any polymerase null mutation abolish the generation of RNPs [19], [20].

Consistently, charge reversal by an E190K mutation abolished the AEP hCC, but not the AEP hCE complex.