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Exact(9)
These results demonstrated that Noc4l-/ mutants were present at the 2-cell embryonic developmental stage at the expected Mendelian ratio.
As expected from our whole-cell current measurements of HEK293 cells, all group 1 mutants were present at the plasma membrane in quantities similar to that for wild-type hNav1.5.
Interestingly, the single C22S and C28S mutants were present mainly as L2 monomers although a small fraction existed as disulfide linked 150 kDa L2-L2 dimers (Fig. 2C, lanes 6 7).
The majority of the mutants were present at the cell surface at comparable levels to the WT (i.e. N-terminally His12-tagged ABCG2) protein (e.g. Figures 2B– 2B).
We cannot formally rule out that K103N mutants were present before ART at a very low frequency <0.5% and that K65R/K103N double mutants were potentially selected.
The VEGF codon 48 and 91 mutants were present in samples with high VEGF-A expression, KIT mutations and of a malignant phenotype.
Similar(51)
Note that since FecXB and FecXG both segregate in Belclare sheep a stable equilibrium cannot be attained when both mutants are present [6], [7].
Second, the characteristic narrow and constricting growth plate from the proliferating zone to the ossification center of c-Myc mutants was present in dcko mice, but not in N-Myc mutants (Fig. 9IA–D').
In contrast, when the catalytically inactive UBE3A mutants are present, the levels of p130 and p107 are restored.
We estimated that purR mutants are present in the unselected cultures at a mean frequency of 0.35 mutants per culture or ∼2.7 × 10−5/10 cells.
By the time a tumor is detected, that is, by the time it reaches 10 cells, the Goldie-Coldman model estimates that drug-resistant mutants are present.
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