Sentence examples for mutants that retained from inspiring English sources

The EC50 of all of the aromatic and/or non-polar mutants that retained efficient pore-forming activity deviated less than 10-fold from the wild-type value under the conditions of our assay (Table 1 and Fig. 3).

Significant upregulation of vegfaa expression was also observed in hemangiosarcomas that were isolated from adult zebrafish mutants that retained one wild-type allele of pten.

Loop deletion mutants and systematic point mutants were then analysed by isothermal titration calorimetry (ITC) to identify those mutants that retained substrate binding capabilities, despite being transport-defective, and therefore were likely to be conformationally restrained.

While SD VE-cadherin barely bound to β-arrestin1 mutants lacking its C-terminus tail (375 418 amino acids), it efficiently interacted with all deletion mutants that retained this region.

After removal of the methanolic incubation solution, mutants that retained significant residual activity could be identified by overlaying with a solution of 1-naphthyl palmitate and Fast Blue B dye suspended in agar, leading to the formation of a dark purple/brown colony when active lipase is present.

The autonomous pathway was originally defined by late-flowering mutants that retain a photoperiod and a vernalization response [29].

MEN1-associated missense menin point mutants can be classified based upon their ability to interact with KMT2A/D and it is believed that those mutants that retain the ability to interact with histone methyltransferase complexes have defects in other functions [14].

Using defined Myc point mutants that retain only certain Myc functions, we have asked how the loss of specific phenotypes affects others, particularly those pertaining to metabolism and transformation.

The active site of the deoxyribonuclease (DNase) activity is also required for ribonuclease (RNase) activity of BGLF5 in vitro [8], although the identification of single function mutants that retain DNase activity and lack shutoff and vice versa [3], [9] indicates that additional residues mediate contacts with viral or cellular factors, or the nucleic acids themselves, to specify the substrate.

PAP mutants that retain polymerase activity but cannot bind Fip1 are nonetheless lethal, indicating that the Fip1 PAP interaction serves an essential function in yeast.

Here, we report that zebrafish mutants that retain a single wild-type copy of ptena or ptenb (ptena +/−ptenb −/− or ptena −/−ptenb +/−) are viable and fertile.