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In contrast with Col-0 fertilized by fbl17 mutants that only allowed 6 8% of transmission efficiency of the fbl17 mutant allele, the fie mutation raised the transmission efficiency of fbl17 to 27 32%.
The ERG recordings differ from Drp1 mutants that only exhibit a loss of on- and off-transients but a normal amplitude.
Prior to this study, the contribution of specific stimuli to PhoQ-mediated bacterial virulence was difficult to ascertain as mutants that only respond to individual signals were not available.
To confirm this, and to test if nephron segmentation defects could also be generated by genetic means, we made use of Apc and Ctnnb1 (the gene encoding β-catenin) mutants that only result in mild increases in β-catenin activity.
The transport efficiency of MsbA decreases dramatically when the structure of LPS is simpler than Kdo2-lipid A. E. coli mutants that only synthesize lipid IVA grow slowly because lipid IVA can not be flipped efficiently by MsbA in the inner membrane (Klein et al., 2009).
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The Sec → Cys mutant of TR1 retains only 2% of the specific activity of the WT enzyme, and the mutants that contain only a partial C-terminal redox center retain only 1% of the activity of the WT enzyme (compare enzymes 3 and 15 with enzyme 1).
However, the hyperproliferation observed in Amotl2a mutants is only partially rescued in mutant zebrafish that lack both Amotl2a and Yap1, and remains higher than in mutants that lack only Yap1.
Here, we used phage display techniques to generate receptor-selective TNF mutants that activate only one TNFR.
We propose that the vast majority of nonsense mutations that affect all three basic dumpy phenotypes are in constitutive exons, whereas nonsense mutants that remove only one or two of the basic functions are in alternatively spliced exons.
Using defined Myc point mutants that retain only certain Myc functions, we have asked how the loss of specific phenotypes affects others, particularly those pertaining to metabolism and transformation.
Fourth, in contrast to the cps and hcf mutants that affect only translation, the rlsb-1/rlsb-2 mutantshoweded variation in accumulation levels for several plastid mRNAs as well.
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