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Agnostic approaches such as incorporating gene-environment interactions in a genome-wide association study setting might identify genetic variants that only affect risk when acting with other factors.
Additionally, MetaCyc includes many alternate pathway variants that only differ by one or two reactions, and these minor variants should not be counted as completely separate pathways when pathway specificity of a reaction is calculated.
This clustering is consistent with the idea that we are more likely to detect deletion variants that only affect part of NIb and are, therefore, likely viable by complementation in trans.
Second, there is growing evidence to suggest that the very same genetic variants that only increase the risk of developing a psychiatric condition if associated with adverse rearing conditions, can lead to better than average outcomes when meeting favorable early environmental condition (high-quality care-giving).
Nine months after 3TC introduction variants that only had the M184V mutation co-existed with variants with linked M184V and T215Y mutations.
For example, as seen in Table 2, 20 × coverage is too low to reliably pick up variants that only comprise 20% of the sequencing sample.
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T47D-Y cells express neither PR-A nor PR-B; these cells were transfected with appropriate PR constructs to obtain variants that express only PR-A (T47D-YA) or only PR-B (T47D-YB) (Sartorius et al, 1994).
This approach allowed us to identify genetic variants that carry only a small disease risk individually, but that jointly can contribute relatively large effects on PMI susceptibility.
Hardest to classify are variants that arise only rarely, of which there are thousands for BRCA1.
In resurfacing, the surface of an antigen outside a target epitope is redesigned to obtain variants that maintain only the target epitope.
This study compared the activity of three histone-derived antimicrobial peptides buforin II, DesHDAP1, and parasin with variants that contain only lysine or arginine cationic residues.
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