Sentence examples for mutants supporting the from inspiring English sources

Considering the results obtained with PaHyPRE mutants supporting the key role of Cys88 and Cys236 residues in catalysis and the large overall structural similarity with TcPRAC, our data supports a reaction mechanism similar to PRAC where HyPRE equally possesses two active sites per dimer, each one including two catalytic Cys.

Importantly, we find that a deletion mutation in ubc-13 that results in an early nonsense codon (and therefore is likely a null; Figure S5) causes the same GLR-1 trafficking defects as observed in uev-1 mutants, supporting the idea that a UEV-1/UBC-13 heterodimer complex is regulating GLR-1 trafficking.

Simultaneously deleting GCN5 and SAC3 does not lead to additive effects compared to the single mutants, supporting the hypothesis that SAGA and TREX-2 function together in the same pathway for what concerns DNA circle retention in the mother cell.

Again, no appreciable transthiolation defects were observed for the mutants, supporting the notion that the ubiquitin-binding surface is not involved in the upstream steps of the enzymatic cascade.

Interestingly, the phenotypes observed in this fly model of the UPRmt were similar to those of parkin and pink1 mutants, supporting the idea that mutations in these PD-related genes in Drosophila might result in a detrimental UPRmt activation.

Furthermore, an increased sensitivity to hypertonicity was observed in double mutants of α-actinin and filamin, in hisactophilin mutants and in LimC, LimD and LimC/D mutants, supporting the importance of the actin cytoskeleton for the cellular resistance to an adverse osmotic environment [ 9- 11].

Experimental data on these mutants supported the assumption.

Our identification of apparently identical tooth phenotypes in Lrp4 and Wise mutants supports the premise that Lrp4 has a role in the modulation of Bmp signalling.

Finally, the virulence defects we observed for the UTI89 ΔhofQ and CFT073 ΔyheF ΔhofQ mutants support the idea that the K12-homologous T2SS and T4P gene clusters are functional and expressed under conditions encountered within the host.

Recent studies on autophagy-specific atg gene mutants support the involvement of autophagy in plant immune responses [ 6, 8].

Experimental studies with these mutants support the behavior of the simulated networks and the involvement of the efflux of anions at the plasma membrane in the process [ 6- 9].