Sentence examples for mutations supporting the from inspiring English sources
This observation suggests that the concurrent CVs might be a mixture of SNPs and mutations, supporting the hypothesis that some CVS in dbSNP are truly phenotypic mutations, and some CVM in HGMD are disease-susceptibility SNPs.
Kinase-impaired BRAF mutants showed a significant association with concomitant activating KRAS or NRAS mutations, but not PIK3CA mutations, supporting the reported interaction of these mutations.
Furthermore, a 5′-phosphorothiolate substitution, which creates a hyperactive leaving group, suppressed deleterious C75 mutations, supporting the role of C75 as a general acid.
Although RIP was not verified experimentally, a detailed analysis for all the repeat families revealed a higher number of transition mutations, supporting the existence of a RIP-like mechanism in M. graminicola, as noted previously [ 12, 13].
EMS is a widely used mutagen that causes random point mutations, supporting the notion that the abnormal traits observed in the field-collected individuals from the Fukushima area originated from genetic mutations.
However, this was not accompanied by HRPT2 mutations, supporting the previous reports that loss of parafibromin immunoreactivity does not necessarily reflect an HRPT2 mutation (Gill et al. 2006, Zhang et al. 2006, Juhlin et al. 2007, 2010).
The Hamming distance values, in addition to the high frequency of recurrent mutations, support the idea of a form of mutational robustness [ 34- 36] evolving in the system through a quasispecies behavior in ligase populations evolved in vitro, although a formal test of this will require a comparison of fitness values.
A recent clinical study of breast tumors containing BRCA mutations supports the hypothesis that PHD3 plays an important role in malignancy.
Molecular evidence including cells harboring mutations of the TSG and recent data on p53 mutations support the field cancerization theory.
The identification of activating BRAF mutations supports the hypothesis that LCH is a process with oncogenic potential [ 20].
Nevertheless, the effects of the sis1 and ydj1 mutations support the assumption that the ATPase cycle of Ssa2p plays an essential role in tRNA import.
