Sentence examples for mutants most of from inspiring English sources

However, clinical trials have revealed rapid selection of resistant mutants, most of which are considered to be pre-existing variants.

With this aim, we selected a number of mutants, most of which related to fALS.

Group B mutants, most of which produced lower CAT activities than that of the vector control, contained 12 TLS mutants; six of which had translation stops at the 62nd, 88th, 92nd, 101st, 134th and 135th amino acid.

We selected eleven SOD1 mutants, most of them reported as pathological, and characterized them investigating their propensity to aggregation using different techniques, from circular dichroism spectra to ThT-binding fluorescence, size-exclusion chromatography and light scattering spectroscopy.

In both groups of mutants, most of the peroxisomal matrix proteins are mislocalized to the cytosol, where they are relatively stable.

The effectiveness of the biased random walk in localizing the RNA is even more clearly demonstrated by stau mutants: most of the mRNA is trapped at the anterior of stau mutant oocytes, and the mRNA that is released into the oocyte cytoplasm moves four times less frequently than in wild-type.

For the S193E mutant, most of the same contact surface between the N-terminus and channel's wall is retained in the simulation.

For example, 3 separate bglG-type genes involved in carbohydrate sensing and transcriptional anti-termination are downregulated in a spo0A mutant, and 7 transcriptional regulators are downregulated in the spo0A mutant, most of which are predicted to respond to nutrients and extracellular cues (Additional file 2).

The predictive power of FOLDEF was tested on a very large set of point mutants (1088 mutants) spanning most of the structural environments found in proteins.

A similar large-scale mutant strategy, "genetic footprinting," was used to generate a collection of Ty1 transposon mutants covering most of yeast chromosome V (Smith et al. 1995, 1996).

Mutants in most of these genes have been shown to induce phenotypes which are similar or sometimes identical to robo mutants.