Also, the mouse genome should help identify the role of human genes, most of which are largely unknown.
Nrf2 activates the transcription of more than 500 genes, most of which are protective and anti-inflammatory.
Furthermore, microarray analyses can result in long lists of altered genes, most of which may be difficult to evaluate for functional relevance.
Although there have been many network-based attempts to discover disease-associated genes, most of them have not taken edge weight – which quantifies their relative strength – into consideration.
The 2935 binding sites were recognized by TFs associated with 1422 unique human genes, most of which (1129) were associated with the Gene Ontology terms "TF activity", "Cofactor activity", or "DNA Binding" (Additional file 3).
Among genes involved in oxygen and electron transfers, the Cytochrome P450 family was represented by 44 up-regulated genes, most of which have a molecular function of monooxygenase activity or iron ion binding.
In addition, in each tissue we observed sex-specific expression differences for some genes, most of which were located on either the X or Y chromosome.
The second half of pLGUG1 harbors a specific insertion spanning 24 kb which consists of a duplicated sequence comprising 17 genes most of them hypothetical.
In this study, we measured the expression stability of 20 candidate reference genes most of which have been previously used as typical PCR reference genes.
While the gene order is not always conserved in clade A-associated cooS genes, most of the genes have a similar genome context.
Regarding underexpressed genes most of them showed the same pattern found in the microarray results (ERRB4, KCNAB1, PPARGC1A, LHX2 and LRRC8B) as seen in figure 3B.
