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Now the mutants have to battle the ur-mutant, the first mutant of all, the ancient Egyptian potentate En Sabah Nur, smaller and more human-sized than in the comics and played with massive impassivity by Oscar Isaac.

Transdominant-negative Tat mutants have to date been mainly defined by their abilities to suppress the transactivation function of HIV-1 Tat [9], [10], [11], [15], [16] and to induce latency during HIV-1 infection [27], [28].

In addition, screening of mutants in some test conditions is problematic because phenotypes of individual mutants have to be evaluated one-by-one.

Besides the routinely used biochemical or pharmacological approaches, methods of reverse genetics (including anti-sense silencing and screening for insertional mutants) have to be employed.

For detailed studies on gene functions, transposon mutants have to be confirmed experimentally in order to rule out secondary mutations, polar effects or leaky phenotypes.

As mutations that improve the function of a biocatalyst are rare (i.e., most mutations either do not change the activity or are deleterious), many mutants have to be screened to at least have a chance of finding desired "hits".

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In our study, since none of the infants or adults had this medical history, the presence of P. jirovecii DHPS mutants has to be discussed.

On the other hand, in order to achieve good xylan conversion, the supernatants produced by the mutant have to be supplemented with additional β-xylosidase activity.

These results indicate a loss of mitochondrial functionality and that this mutant has to rely on other pathways, such as glycolysis, for energy production.

Professor Xavier and his mutant buddies have to figure out a way to save both the humans and the mutants, and the solution is to send Wolverine back into the past to change history.

Whereas SOX17 has been engineered to replace SOX2 in the pluripotency circuitry, all generated SOX2 mutants have failed to act like SOX17.

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