Sentence examples for mutants designed to from inspiring English sources

We investigated four new λ6 85⁎ mutants designed to fold especially rapidly.

Here, we describe the analysis of the pH-dependent stability of 13 mutants designed to probe the nature of the Lys12 denatured state interaction.

Influenza haemagglutinin (HA) and HA-derived mutants designed to locate primarily to secretory or endocytic membranes were present in PLD1-positive membranes.

We have further characterised Pex10p's E3 ligase activity using mutants designed to disturb this activity and show that Pex10p acts as the E3 ligase for Ubc4p-dependent ubiquitination of Pex5p but not Pex4p-dependent ubiquitination in vivo.

Herein we report the stability and thermal dependence of the activity of wild-type Bacillus pumilus lipase (BplA) and four site-directed mutants designed to improve its thermal stability.

Mutants designed to compromise heterotetramerization or the DNA-protein contacts around the heterotetramer strongly reduce the DNA binding and supercoiling activities in vitro and compromise kinetochore assembly in vivo.

Herein we describe the development of a novel engineered TEVp mutant designed to be active in the secretory pathway.

This growth arrest can be rescued by exogenous expression of the fusion and a mutant designed to prevent translation of the ELK4 protein.

Bungarus fasciatus acetylcholinesterase (BfAChE) was engineered to acquire organophosphate hydrolase (OPase) activity by reproducing the features of the human butyrylcholinesterase G117H mutant, the first mutant designed to hydrolyse OPs.

To study the role of AKAP5 in behavior and synaptic plasticity, we created two AKAP5 mutant lines of mice, a null allele, or knockout (KO) and an AKAP5 mutant designed to express a truncated protein missing the PKA binding domain (D36).

A mutant unable to hydrolyse ATP (K304A in the Walker A box) and a mutant designed to abrogate the nuclease activity (D10A/E12A) were generated by directed mutagenesis.