Extended Data Fig. 2 Analysis of effector function in 1928ζ mutants compared to wild-type 1928ζ.
Extended Data Fig. 6 In vivo T cell exhaustion of TRAC-1928ζ TRAC-1928ζmutantsto wild-type TRAcompared
Affinity for sulfonamides/sulfamates was decreased in all three mutants compared to wt hCA II.
By contrast, AN responses to increasing Ci quantities were reduced significantly (P < 0.01) in mutants compared to WT or Comp GFP plants (Fig. 4).
Our analysis revealed a significant delay in the peak times of Afh mutants compared to wild-type mice during the LD condition.
Among the P53 target genes, we identified and validated transcripts whose levels were increased at least 50% in the mutants compared to controls.
To test this hypothesis, we used three methods to measure gm in atpip1 4 mutants compared to WT or Comp GFP plants.
This observation is further corroborated by the decreased levels of ATP in the deletion mutants compared to the control, accompanied by unchanged levels of ROS (Fig. 1d).
This latter effect results from NREM fragmentation (i.e., increased NREM episodes) and low delta power expressed by Afh mutants compared to wild-type mice.
We observe that sequential evolution takes a lot longer to create m-hit mutants compared to the cooperation/cheating scenario, regardless of the presence of recombination.
a, Fold change in the length of poly(A) tails (measured by TAIL-seq) in cde-1 mutants compared to wild type.
