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Exact(23)
The high affinity mutants described here thus provide critical insight into the molecular basis of TSST-1 specificity and serve as potential leads toward the development of therapeutic agents for superantigen-mediated disease.
All the mutants described here were cloned into pGEX-6P-1 vector.
In agreement with the above, the three c-CBL mutants described here appear to have tumor growth and metastasis promoting properties.
Table 3 summaries the hydrodynamic properties of BASS mutants described here.
But in the sec8 mutants described here, trafficking of both A- and B-type receptors was affected.
A consistent theme in the caspase-3 mutants described here is the transient rotation of the catalytic H121 toward C163.
Similar(37)
Thus, the mutant described here represents the first report of a BCR-ABL mutant retaining kinase activity that is completely transformation deficient in vivo.
The T192 mutant described here was originally isolated in a large scale genetic screen devised to obtain mycoplasma gliding mutants and accordingly, 54.4% of the cells from this mutant are non-motile.
In addition to the conclusion derived from the use of phospho-mutants described here, other evidence supports the idea that phosphorylation disables anti-apoptotic activity.
In the mutant described here, the N-terminal PDZ domain of periaxin was deleted.
However, the sor1 mutant described here was the only mutant with a near complete reversion to the wild-type phenotype and this was clarified in the methods section.
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