Sentence examples for mutations described here from inspiring English sources

Antagonists of the mTOR pathway, such as rapamycin, can ameliorate some of neurological deficits associated with mTOR hyperactivity33,34,35, 36, 37. To evaluate whether this is true for the RHEB activating mutations described here, we treated the neurons with 20 nM rapamycin or vehicle 1 day after transfection for 3 days and assessed neuronal soma size.

However, three of the mutations described here (A360V, I506L and Q547K) were present only in NRTI-experienced isolates.

In contrast, the mutations described here were created in two overlapping tranches, each of ∼10 weeks in duration, from donor creation to isolation of the final clones.

The significance of the large pfserca polymorphism and the consequences of the mutations described here on the protein's function and regulation are unclear.

A small number of NNRTI-experienced patients was present in the dataset, and as possible interactions between NRTI- and NNRTI-selected mutations is known to occur, we cannot completely discard a putative effect of NNRTI in the selection of mutations described here.

The mutations described here may guide the engineering of new far-red monomeric FPs.

Functional genomics studies will inform whether the mutation described here, or its haplotypic background, has an impact on MSTN gene expression.

In contrast to the dominant mutation described here, siRNA knockdown of LMNA does not affect the LMNB network in HeLa cells [4].

However, as the mutation described here affects an acceptor-splice site and leads to skipping of the upstream exon in the two-exon-skip outcome, these findings illustrate that the exons involved in the two-exon-skip splicing outcome do not solely depend on whether the mutation affects an acceptor- or donor-splice site.

The I179N mutation described here does not occur at the C-terminus; however, PDZ domains do bind to, and interact with, proteins at internal, that is non C-terminal, sequences although such internal binding is rare and poorly understood [23], [32] [37].

The missense mutation described here leads to a change from arginine to cysteine.