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Exact(5)
In a few cases, we also observed some variability in the amount of red mutant tissue in animals raised at 18° where tissue ablation does not occur.
The membrane localisation of Chico-RFP was only slightly reduced in lnk mutant tissue in comparison to wild-type tissue, probably due to the PH domain of Chico.
In contrast, we did not notice patches of mutant tissue in adult G0 flies when targeting ebony or yellow, indicating that mutations in somatic cells after pDCC6 injection are rare, despite efficient targeting in the germline.
Since EdU measures S phase cells, it is possible there might be delays in G2/M phase in the mutant tissue in this genotype to account for this effect.
Since the reduction of Slif affects the growth of the wild-type and the PTEN mutant tissue in a differential manner, this amino acid transporter could represent a target for a dosage-dependent drug therapy of tumors with PI3K activation.
Similar(54)
(H ) PcG components ph-p and Psc are downregulated in scrib and dlg mutant tissue (average in green), similar to levels observed upon JNK activation (blue).
We compared the amount of red mutant tissue present in unirradiated animals to that found in animals subjected to IR during the early L3 larval stage.
One set of F2 progeny was maintained at 18° until adult eclosion and was screened for a reduction in the amount of red (mutant) tissue present in the adult eye.
(A ) Under standard conditions (normal food), the PTEN mutant tissue overgrows in a hypertrophic manner.
This overrepresentation of the mutant tissue resulted in an absolute increase of eye size under starvation as compared to normal food conditions.
It is therefore interesting to speculate that owing to the altered biomechanical properties of the mutant tendons, some microdamage could occur in the mutant tendon, and the increased number of fused fibrils may be indicative of repair mechanisms in the mutant tissue, which could in turn affect the biomechanical properties of the tissue.
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