Sentence examples for mutant supporting the from inspiring English sources

Furthermore, mutation of dlk-1 suppressed a microtubule acetylation mutant supporting the idea that altering microtubule structures is an upstream signal for DLK-1 activation.

The expression of both UNC-40 and MADD-2 in vm2 was significantly down-regulated in the lin-12 wy750) lin-12 wy750orting the idea that lin-12 was required for the expression of unc-40 and mutant in vm2.

As shown in Figure 2B, the increase in transcript size observed in the rrp6-ts32 mutant was almost completely lost in the rrp6-ts32 pla1-ts37 double mutant, supporting the idea that the increase was caused by polyadenylation.

Neomycin resulted in slower FRAP recovery of WT α-actinin-2 (≈40 ± 4 s), similar to the PIP2 mutant, supporting the notion that α-actinin-2 Z-disk dynamics are strongly dependent on PIP2 regulation, in agreement with the Z-disk localization of PIP2.

Even in the muscle lineage, several cell-type specific reporters displayed wild type patterns in lin-12 wy750) lin-12 wy750orting the notion that mutantsupportingthe vm2 differenotionon remain inthat while only a subset of genes that determanys specific postsynaspectsevelofmenthere affected.

Moreover, the repression of MMS22 led to a partial rescue of the sensitivity of the P MET3-CSM3 or P MET3-MRC1 mutont to MMS and HU, whereas the repression of MMS22 caused increased the sensitivity to CPT and IR of the P MET3-MRC1 mutant, supporting the idea that Mms22p is required for responding to paused replication forks.

A second cryoEM reconstruction of a truncated VCC mutant supported the topology of our model in which the carboxyl-terminal lectin domain forms "spikes" around the toxin core with the putative carbohydrate receptor-binding site accessible on the surface of the oligomer.

Since pentamers are required to close icosahedra built from hexamers, the phenotype of the mutant supports the proposed role of this protein in the carboxysome shell.

However, the observation that the notching phenotype can be enhanced by loss of dTcf and rescued by gain of Wg, as seen with the zw3+/− heterozygous mutant, supports the hypothesis that vg>Mad and vg>Med suppress Wg signaling activities, therefore leading to the terminal consequence: apoptosis in the wing margin.

This large deletion mutant supported the finding.

Although our analysis of the cxcr3.2 mutant supports the role of Cxcr3.2 in macrophage chemotaxis to infections, the chemokine ligands that signal via this receptor are unknown.