Sentence examples for mutant load in from inspiring English sources

One interesting point is that the median of the absolute number of mutants actually remains constant if we compare the Fos-R mutant load in mice receiving fosfomycin or not, although the total bacterial count decreased by two orders of magnitude in the dosed mice.

There is indeed no available data correlating intermediate mutant load in the prenatal period with the postnatal outcome.

Mutant load in these BBSs loci appears to be associated with the severity of clinical phenotype [ 17].

We thus found a statistically significant correlation between the mean mutant load in each of the five lymphocyte pools and the heteroplasmy distribution at the single-cell level.

Single muscle fibre analysis has revealed levels of pathogenic mtDNA deletions above a critical threshold level of >80% mutant load in these COX deficient fibres.

We similarly did not find any temporal variation of the MELAS mutant load in multiple samples taken within 10 to 39 GW (Tables 4A and B).

Our group found similar mutant loads in chorionic villi and amniocytes from three heteroplasmic fetuses [Bouchet et al., 2006].

It is difficult to reconcile the prenatal intertissue stability observed in this study, and the tissue-dependance of m.3243A > G mutant loads in adult carriers, who harbor heteroplasmy rates almost constantly higher in skeletal muscle, urinary epithelial tract cells, and hair follicles, than in white blood cells [Chinnery et al., 1999; Frederiksen et al., 2006; Whittaker et al., 2009].

Because mutations such as m.3243A > G exhibit a relatively normal pattern of distribution around the maternal mean, it would be unlikely, given the relatively small sample size and the mean maternal mutant load value in majority below 40% (in blood) in our series (Table 1) to find embryos with greater than 80% heteroplasmy, even in the absence of selection.

This transmission risk fits with the MELAS transmission rate calculated from the mutant load determined in buccal mucosa samples from carriers' offspring in the postnatal period [Uusimaa et al., 2007].

Using DNA from five adult carrier females, we therefore recapitulated Saitoh's study with our own method of mutant load assessment, in an effort to homogenize our data.