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However, the CI results revealed that this mutant is actually less competitive than the wild-type (Figure 6B).

The combination leads to lung cancer cell survival, indicating that the T790M mutant is actually an oncogene.

Secondly, the SA content that remains in the eds5-3 mutant is actually not produced in the plastid.

This is consistent with the ex-vivo clonogenicity assays wherein the mutant is actually more limited in its ability to support the growth of GMP.

The argument that the transgene rescues the yan mutant is actually quite weak, because it is possible that developing animals that can tolerate very different expression levels can also tolerate very different decay dynamics.

More recently, it was found that the Opi− phenotype of a reg1 mutant is actually due to the altered protonation status of PA, as a function of cellular pH, which affects Opi1 translocation to the nucleus (Young et al. 2010).

Investigating this contamination, we found that: 1) it was coming from the ΔligB mutant, which was apparently harboring a prophage of a temperate bacteriophage; 2) that the DNA damage sensitivity of the original ΔligB mutant was actually separable from the ΔligB defect by P1 transduction and was fully due to the prophage.

The kcat of the Arg301Ala mutant was reduced ∼100-fold, but the kcat of the Arg301Lys mutant was actually slightly increased compared to that of 17X-PTDH.

Seven out of the 15 residues from the grafted loop-1 region in the A3BCD2 mutanttare actuallyally conserved between A3BCD2 and A3A.

It is therefore possible that the phenotypes of bud19 and ydr433w deletion mutants are actually caused by inactivation of the overlapping RPL39 and NPL3 genes, respectively.

Although most investigators consider nuclear expression to be an indication of P53 gene mutation, cytoplasmic accumulation of mutant P53 is actually present in some tumors, including colorectal cancer, lung tumors and melanoma [ 19, 20].