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The mutual suppression between these mutations is actually a special case from a range of possible parameter-dependent outcomes.
Importantly, although the ti/tv rate is lower, the number of non-synonymous mutations is actually higher for EMS compared to ENU.
Although no disorder associated with RSK3 mutations is actually known, these results suggest that this gene may have a specific function in these organs [ 20].
Recurrence of mutations is actually a predicted characteristic of quasispecies [ 5], thus providing additional support for this interpretation of these data.
This indicates that the 'constitutively active' Wnt signalling caused by APC/CTNNB1 mutations is actually still modulated by tumour cell intrinsic and/or extrinsic factors (Fodde and Brabletz, 2007).
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In one study, G34 mutations were actually associated with improved OS when compared to wild-type H3.3 (Sturm et al., 2012).
Now it appears that what Davis thought were mutations are actually "pseudogenes" --bits of nuclear DNA that resemble working genes but don't churn out proteins.
A few mutations were actually not recorded, either by systematic employment of a wrong reference sequence or through oversight.
Furthermore, 5 out of the 8 mutations in the head of the F protein are concentrated in a short invariable region at position 364 411, suggesting that the observed mutations are actually selected over time by the host immune responses.
However, we observed good growth of the first high-confidence evolutionary intermediates in which these mutations were actually fixed.
Moreover, we cannot assume that all distinguishing mutations were actually recorded, since it has been stated that TTGE can detect many but not all mutations [ 28].
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