Sentence examples for mutant has very from inspiring English sources

It is also likely that the C-terminal is essential for stability both in the WT nsp4C and C425S mutant, since the expression of a ΔF484-Q496 deletion mutant has very low yield compared to the WT nsp4C protein.

The C128A mutant has very interesting kinetics in that its open state outlast the activation light pulse by many orders of magnitude but it still spontaneously inactivates within an experimentally accessible time window.

These experiments qualitatively agree with the dynamics reported by Ma et al. for the W303 background: 1) the pde2 Δ mutant has very similar cAMP dynamics to the wild-type background; and 2) the pde1 Δ mutant reaches a much higher cAMP maximum.

Specifically, in R975A, the onset of the voltage-induced outward currents was instantaneous upon depolarization and only very small tail currents were inwardly directed upon repolarization from +200 mV to −70 mV, indicating that the mutant has very fast gating kinetics or that the inward movement of cations through the conduction pathway of the channel is blocked at negative membrane potentials.

This role of Glu is consistent with the findings that the E473Q mutant has very low activity 4000-foldd lower than that of the wild type) (44) and the E473D mutant 1000-foldd less active than the wild type) is mainly deficient in the C−C bond forming step (A → B) and the decarboxylation (C → D) (45).

It appears that all these 8 BubR1 forms, including WT and the 3D mutant, have very comparable Kd's with B56γ1 (Table 2), indicating that aspartate cannot mimic the effect of phosphor-serine/threonine in any of these three sites.

Despite the high level of expression, the S98D mutant had very low activity in both repressing and derepressing conditions.

This indicated that the His20Ala mutant had very little if any activity and pointed to time-dependent aggregation of His20Ala - RNA18 complex es).

We found that the hrde-1 mutant had very similar H3K9me3 defects to the nrde-2 and nrde-4 mutants.

As expected from the regulatory hierarchy just described, the gi mutant had very low transcript levels of FT [ 14].

The Phe300Gln mutant had very low activity and was not activated by bicarbonate at concentrations <2 mM (Fig. 8) and higher concentrations exhibited non-saturation.