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Exact(5)
Thus, the mutant described here represents the first report of a BCR-ABL mutant retaining kinase activity that is completely transformation deficient in vivo.
The T192 mutant described here was originally isolated in a large scale genetic screen devised to obtain mycoplasma gliding mutants and accordingly, 54.4% of the cells from this mutant are non-motile.
In the mutant described here, the N-terminal PDZ domain of periaxin was deleted.
However, the sor1 mutant described here was the only mutant with a near complete reversion to the wild-type phenotype and this was clarified in the methods section.
This is also indicated by the fact that the glu1-2 mutant described here develops more slowly than wild-type plants when grown on soil, but does eventually complete its life cycle (data not shown).
Similar(55)
The high affinity mutants described here thus provide critical insight into the molecular basis of TSST-1 specificity and serve as potential leads toward the development of therapeutic agents for superantigen-mediated disease.
All the mutants described here were cloned into pGEX-6P-1 vector.
In agreement with the above, the three c-CBL mutants described here appear to have tumor growth and metastasis promoting properties.
Table 3 summaries the hydrodynamic properties of BASS mutants described here.
But in the sec8 mutants described here, trafficking of both A- and B-type receptors was affected.
A consistent theme in the caspase-3 mutants described here is the transient rotation of the catalytic H121 toward C163.
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