Sentence examples for multitude of alterations from inspiring English sources

Tumorigenesis is characterized by the accumulation of a multitude of alterations.

Gene expression profiling and genome-wide sequencing of human breast tumors has revealed a multitude of alterations [ 31- 33].

In addition, it has been suggested that during transformation PML RAR α induces a multitude of alterations in the chromatin architecture.

Finally, a multitude of alterations involving the apoptotic signaling pathways downstream the microtubule complex, as well as aberrant expression of microRNA, have been also found in resistant tumors.

The high prevalence of uORFs in the human transcriptome suggests that intensified search for mutations within 5′ RNA leader regions may reveal a multitude of alterations affecting uORFs, causing pathogenic deregulation of protein expression.

Although the latter is most expensive and time-consuming, whole-genome data can be mined for the multitude of alterations that commonly occur in cancer genomes, including structural variants such as chromosomal translocations, large-scale rearrangements and deletions that often fuse exons to create new fusion proteins.

The major challenge for the future will be determining the pathogenicity of the causal mutation among a multitude of genetic alterations.

Molecular imaging helps individualize patient treatment Through growing evidence from genetic profiling it is understood that cancer is not a single homogeneous disease, but that it is represented by a multitude of genetic alterations and changes at the cellular level.

At higher Pb doses, pathways that are altered by lower doses of Pb are likely to be indistinguishable in the multitude of drastic gene alterations that accompany more general toxic responses (e.g., oxidative stress, heat-shock protein associated expression, apoptosis).

A multitude of studies have implicated alterations in the hypothalamo-pituitary-adrenal (HPA) axis in the vulnerability to develop stress-related disorders like major depression [1] [7].

Tumorigenesis is a multistep process characterised by a multitude of genetic and epigenetic alterations.