A large number of research advances in detection and quantification of 5mC have assisted epigenetic modifications to be connected to a plethora of phenotypic alterations (Richards, 2006), that may form an independent part of the forensic study or corroborate the existing STR results.
Inhibition of HDACs leads to a plethora of cellular alterations, which are difficult to control.
Recent cancer genome projects have identified a plethora of genomic alterations, such as deletions, inversions and translocations [ 3].
Given the plethora of genetic alterations observed in primary breast cancers, it has been difficult to establish which are involved in initiation, progression and metastasis.
The plethora of genomic alterations in cancer that directly involve transcription factors highlights the potential of transcription factors as anticancer drug targets.
Clinical and investigational experience has shown that primary traumatic muscle injury induces a plethora of pathological alterations known to converge in secondary structural and functional deterioration [ 1].
Epigenetics alterations are involved in the pathogenesis and progression of kidney disease, especially because these alterations are easily promoted by the plethora of coexisting metabolic alterations and inflammation associated with CKD [ 34].
See related commentary by Zahed and Gupta, Traumatic brain injury (TBI) induces a plethora of structural and functional alterations, which contribute to subsequent deterioration as observed under clinical and experimental conditions.
Studies in animal models of maternal infection have demonstrated a plethora of behavioral, molecular and structural alterations relevant to schizophrenia in the adult offspring [5] [16].
To understand the processes involved, it is necessary to unravel signalling pathways, complex interaction networks and metabolic alterations involving a plethora of anatomical components.
