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Exact(5)
To address this design problem, we sought to identify a single, common motif (a "common receptor") shared by multiple structurally and functionally diverse proteins implicated in AD.
The ATP-Binding Cassette transporters ABCG2, ABCB1 and ABCC2 form a unique defense network against multiple structurally and functionally distinct chemotherapeutics, thereby resulting in MDR.
This finding underscores the importance of alternative splicing, through which a single gene can generate multiple structurally and functionally distinct protein isoforms.
Mitf gene exhibits a split promoter design, which allows it to generate multiple structurally and biologically distinct proteins (Hershey and Fisher 2005).
A number of membrane proteins have been identified that recognise multiple structurally and chemically diverse solutes (Koepsell, 2013; Pelis and Wright, 2014).
Similar(55)
Multidrug resistance (MDR) is defined as resistance of tumor cells to the cytotoxic action of multiple structurally dissimilar and functionally divergent drugs commonly used in chemotherapy.
RAGE binds multiple structurally diverse ligands and is considered a pattern recognition receptor, but the structural basis for RAGE binding to multiple ligands is not well understood.
The customized selection scheme was designed to identify mutants that could transport multiple, structurally diverse substrates and preserve polyspecificity, an important quality of Pgp.
As a final point, in vivo multiple structurally divergent antigens can bind and stimulate CLL B cells through the BCR.
Efflux proteins belonging to all five transporter families are involved, and frequently can transport multiple structurally unrelated compounds resulting in a multidrug resistance (MDR) phenotype.
A degenerate system contains multiple structurally distinct elements performing similar functions (Box I and II; Figure 1).
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