Sentence examples for many structurally and from inspiring English sources

In addition, cancer cells often express mechanisms that confer simultaneous resistance to many structurally and functionally unrelated drugs.

Among many structurally and functionally different synthetic macrocycles, cucurbit[n]urils (CB[n]) are an interesting family of host molecules [4 9] consisting of a hydrophobic inner cavity with two identical carbonyl-laced portals.

The mechanism by which Pdr5p recognizes so many structurally and functionally unrelated substrates remains an enigma [21].

Multidrug resistance (MDR) remains a major cause for failure of chemotherapy-based treatment of breast cancer, in which cells become refractory to many structurally and functionally unrelated chemotherapeutic drugs.

For example, 4-legged animals or round fruits have many structurally and semantically similar neighbours that compete for selection (Humphreys et al., 1995; Joseph and Gathers, 2003; Joseph and Proffitt, 1996; McRae et al., 1999).

Many structurally and functionally distinct SXR activators inhibited the proliferation of MCF-7 and ZR-75-1 breast cancer cells by inducing cell cycle arrest at the G1/S phase followed by apoptosis.

Many structurally (steroidal and nonsteroidal) and mechanistically (principally reversible and irreversible) diverse inhibitors have been developed.

In other words, this AFGP molecule has many structurally distinct and energetically equal minima in its energy landscape.

Finally, knowledge of the chemical structure of pure drugs enabled laboratory synthesis of many structurally related compounds and the development of valuable drugs.

In unsupervised clustering in high dimensions, feature selection is likewise essential for discerning the underlying grouping tendency that may be 'buried' in a much lower-dimensional subspace – with many structurally irrelevant features and only a small sample size, clustering algorithms are likely to identify false group structure.

G4G3N and G4G15 are 'minimal' G4 sequences and can only form one G-quadruplex configuration with 3 G-planes, while G4G5N and G4G23 contain additional Gs and can form many structurally different G-quadruplex structures with up to five stacked G-planes.