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Study of the samples with light and electron microscopes revealed multiple signatures of shocked quartz, as well as glassy areas that implied a history of fiery melts.
RNA profiling of Scrib mutant tumors reveals multiple signatures of neoplasia, including altered metabolism and dedifferentiation.
Today, a plethora of statistical tests are proposed to identify the multiple signatures of natural selection.
Linnen et al. (2013) studied coat color adaptation in deer mice controlled by a single large gene that shows multiple signatures of sweeps.
The method was introduced in [ 12] (a brief description of TIE* is also given in [Additional File 2]) to enable probabilistic modelling of multiple signatures of the disease.
By examining multiple signatures of genetic drift, we tested if the genomic expansions observed in lineages of Ascomycota fungi resulted from adaptive or nonadaptive processes.
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Furthermore, while several signatures are recurrent in multiple cancers (see below), inter-cancer differences are remarkable in their combination of multiple signatures for each cancer type.
We investigated the source of multiple signatures by the numbers of reads containing homopolymer INDELs inferred by the CIGAR code.
The concordant presence of multiple signatures (detected by population genetic testing) of positive selection on a single region of the human genome is unlikely due to the different mechanisms.
Specifically, it is now possible to simultaneously discover the existence of multiple signatures and assess the relative contribution of each signature to each tumor's catalog of somatic mutations [ 8, 75, 76].
Thus, the overuse of multiple signatures may further complicate the problem of multidimensionality, and different gene signatures should be properly compared and analysed considering their interrelationships and multidimensionality.
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