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Exact(5)
Regulation of α-toxin expression is complex and involves multiple regulators that include agr, sarA homologues, or svrA [ 32- 35].
So far, mutually exclusive splicing regulation has been explained by the outcome from the balance of multiple regulators that enhance or repress either of alternative exons discretely.
So far, mutually exclusive splicing regulation is widely believed as the outcome from the balance of multiple regulators that enhance or repress either of alternative exons discretely [19], [20].
For some components, there may be multiple regulators that are active in one updating event and the combinatory effect is determined by comparing the number of activating to inhibitory factors.
Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system.
Similar(53)
However, the complexity of multiple interacting regulators that govern these effects in cells make in vitro biochemical methods vastly more powerful to elucidate the underlying mechanisms.
These findings indicate that the PcG/TrxG targets are regulated by multiple positive and negative regulators that facilitate the establishment and removal of PcG repression.
Recent studies in prokaryotes have revealed the existence of antisense and alternative transcripts and multiple regulators per gene that imply a highly dynamic transcriptome more similar to that of eukaryotes than first thought [ 2].
Moreover, engineering of global regulators that have multiple functions (as in the case of irrE) may provide ways to simultaneously make alterations at the transcriptomic, proteomic, and perhaps post-translation regulation levels, and thus lead to rapid and significant improvements in cellular tolerances.
The high variance in the interactivity of sequences presents an ideal evolutionary substrate to recruit sequence-specific regulators that target multiple gene products.
Therefore most trans regulators that effect multiple genes might have small individual effects making them hard to detect by genetic mapping and give the misleading impression that cis regulation is the dominant form.
Related(20)
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