Results from our present study suggest that multiple genetic regulations that are potentially linked with such traits or other related/unexplored physiological characteristics may also differ between RR- and WT-WCR (Table 1).
This underexpression could be in part the result of chromosome 4q deletion but also the consequence of multiple regulation loops that are deregulated in cancer cells.
Nevertheless, these sHSP genes were reported as rpoH-dependent in S. meliloti, suggesting multiple regulation mechanisms that may allow a dynamic stress response.
WITH convicted criminals allowed multiple appeals and labour regulations that are a standing invitation to sue one's employers, you might have thought there would be plenty of work to go round for all the lawyers in Brazil.
MAPK signaling modules provide multiple levels of regulation that confer signal amplification and specificity toward a desired outcome [ 4].
We interpret our results as demonstrating that the multiple layers of regulation that allow cells to polarize rapidly and accurately also make it possible for them to adapt, by evolution, to very strong perturbations.
However, the IL-10/JAK1/STAT3 AIR, like all signalling pathways, has multiple levels of regulation that should also be taken into account as these may illuminate additional points for therapeutic intervention.
The scripting/rule-based modelling approach to generating reactions is applicable to other proteins that undergo multiple regulations in a similar manner, for example the insulin receptor substrate IRS-1 [129]–[131] and the C elegans transcription factor SKN-1 (orthologous to NRF TFs in higher organisms) [132].
The expression of one gene can be regulated by several miRNAs, presupposing multiple methods of gene regulation that include dependence on the expression of intronic miRNAs.
For example, with multiple regulations, it is to be expected that the fully phosphorylated form will appear as a concave-upwards function of time, such as a cubic function when three phosphorylations occur, in response to a step increase of the enzyme producing it, rather than the linear timecourse of the 1° model.
